Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

Juan I. Garaycoechea, Gerry P. Crossan, Frederic Langevin, Maria Daly, Mark J. Arends and Ketan J. Patel ()
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Juan I. Garaycoechea: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Gerry P. Crossan: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Frederic Langevin: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Maria Daly: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Mark J. Arends: University of Cambridge, Addenbrooke’s Hospital
Ketan J. Patel: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

Nature, 2012, vol. 489, issue 7417, 571-575

Abstract: The function of haematopoietic stem and progenitor cells is impaired by damaged DNA; here, endogenously generated aldehydes are found to be one source of such damage, which is repaired by the Fanconi anaemia pathway.

Date: 2012
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DOI: 10.1038/nature11368

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