Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

Jakob von Moltke, Norver J. Trinidad, Mahtab Moayeri, Alexander F. Kintzer, Samantha B. Wang, Nico van Rooijen, Charles R. Brown, Bryan A. Krantz, Stephen H. Leppla, Karsten Gronert () and Russell E. Vance ()
Additional contact information
Jakob von Moltke: University of California at Berkeley
Norver J. Trinidad: University of California at Berkeley
Mahtab Moayeri: Laboratory of Parasitic Diseases, Microbial Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Alexander F. Kintzer: University of California at Berkeley
Samantha B. Wang: Vision Science Program, School of Optometry, University of California at Berkeley
Nico van Rooijen: Faculty of Medicine, Vrije Universiteit
Charles R. Brown: University of Missouri
Bryan A. Krantz: University of California at Berkeley
Stephen H. Leppla: Laboratory of Parasitic Diseases, Microbial Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Karsten Gronert: Vision Science Program, School of Optometry, University of California at Berkeley
Russell E. Vance: University of California at Berkeley

Nature, 2012, vol. 490, issue 7418, 107-111

Abstract: Induction of an eicosanoid storm is shown to be an unexpected consequence of inflammasome activation in peritoneal macrophages, leading to vascular leakage and rapid death in mice.

Date: 2012
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DOI: 10.1038/nature11351

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