Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

Roland Schmitz, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wenming Xiao, Meili Zhang, George Wright, Arthur L. Shaffer, Daniel J. Hodson, Eric Buras, Xuelu Liu, John Powell, Yandan Yang, Weihong Xu, Hong Zhao, Holger Kohlhammer, Andreas Rosenwald, Philip Kluin, Hans Konrad Müller-Hermelink, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elias Campo, Elaine S. Jaffe, Jan Delabie, Erlend B. Smeland, Martin D. Ogwang, Steven J. Reynolds, Richard I. Fisher, Rita M. Braziel, Raymond R. Tubbs, James R. Cook, Dennis D. Weisenburger, Wing C. Chan, Stefania Pittaluga, Wyndham Wilson, Thomas A. Waldmann, Martin Rowe, Sam M. Mbulaiteye, Alan B. Rickinson and Louis M. Staudt ()
Additional contact information
Roland Schmitz: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Ryan M. Young: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Michele Ceribelli: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Sameer Jhavar: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Wenming Xiao: Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health
Meili Zhang: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
George Wright: Biometric Research Branch, DCTD, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Arthur L. Shaffer: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Daniel J. Hodson: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Eric Buras: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Xuelu Liu: Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health
John Powell: Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health
Yandan Yang: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Weihong Xu: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Hong Zhao: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Holger Kohlhammer: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Andreas Rosenwald: University of Würzburg, 97080 Würzburg, Germany
Philip Kluin: Groningen University Medical Center, University of Groningen, 9713 GZ Groningen, The Netherlands
Hans Konrad Müller-Hermelink: University of Würzburg, 97080 Würzburg, Germany
German Ott: Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, 70376 Stuttgart, Germany
Randy D. Gascoyne: British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
Joseph M. Connors: British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
Lisa M. Rimsza: University of Arizona
Elias Campo: Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
Elaine S. Jaffe: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Jan Delabie: Pathology Clinic, Rikshospitalet University Hospital, 0372 Oslo, Norway
Erlend B. Smeland: Institute for Cancer Research, Rikshospitalet University Hospital and Center for Cancer Biomedicine, University of Oslo, 0310 Oslo, Norway
Martin D. Ogwang: St. Mary's Hospital Lacor, Gulu 256, Uganda
Steven J. Reynolds: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Richard I. Fisher: James P. Wilmot Cancer Center, University of Rochester School of Medicine, Rochester 14642, New York, USA
Rita M. Braziel: Oregon Health and Science University
Raymond R. Tubbs: Cleveland Clinic Pathology and Laboratory Medicine Institute
James R. Cook: Cleveland Clinic Pathology and Laboratory Medicine Institute
Dennis D. Weisenburger: University of Nebraska Medical Center
Wing C. Chan: University of Nebraska Medical Center
Stefania Pittaluga: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Wyndham Wilson: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Thomas A. Waldmann: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Martin Rowe: School of Cancer Sciences, Birmingham Cancer Research UK Centre, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Sam M. Mbulaiteye: Infections and Immunoepidemiology Branch, National Cancer Institute, NIH
Alan B. Rickinson: School of Cancer Sciences, Birmingham Cancer Research UK Centre, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Louis M. Staudt: Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA

Nature, 2012, vol. 490, issue 7418, 116-120

Abstract: RNA sequencing of Burkitt lymphoma tumours allows identification of mutations affecting the transcription factor TCF3, its negative regulator ID3 and the cell cycle regulator CCND3; these pathways reveal new targets for potential therapeutic intervention.

Date: 2012
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DOI: 10.1038/nature11378

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