Paramutation in Drosophila linked to emergence of a piRNA-producing locus

Augustin de Vanssay, Anne-Laure Bougé, Antoine Boivin, Catherine Hermant, Laure Teysset, Valérie Delmarre, Christophe Antoniewski () and Stéphane Ronsseray ()
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Augustin de Vanssay: Laboratoire Biologie du Développement, UMR7622, CNRS-Université Pierre et Marie Curie, 9 quai Saint Bernard, 75005 Paris, France
Anne-Laure Bougé: Drosophila Genetics and Epigenetics, CNRS URA2578 - Institut Pasteur
Antoine Boivin: Laboratoire Biologie du Développement, UMR7622, CNRS-Université Pierre et Marie Curie, 9 quai Saint Bernard, 75005 Paris, France
Catherine Hermant: Laboratoire Biologie du Développement, UMR7622, CNRS-Université Pierre et Marie Curie, 9 quai Saint Bernard, 75005 Paris, France
Laure Teysset: Laboratoire Biologie du Développement, UMR7622, CNRS-Université Pierre et Marie Curie, 9 quai Saint Bernard, 75005 Paris, France
Valérie Delmarre: Laboratoire Biologie du Développement, UMR7622, CNRS-Université Pierre et Marie Curie, 9 quai Saint Bernard, 75005 Paris, France
Christophe Antoniewski: Drosophila Genetics and Epigenetics, CNRS URA2578 - Institut Pasteur
Stéphane Ronsseray: Laboratoire Biologie du Développement, UMR7622, CNRS-Université Pierre et Marie Curie, 9 quai Saint Bernard, 75005 Paris, France

Nature, 2012, vol. 490, issue 7418, 112-115

Abstract: A paramutation occurs between two alleles in the same locus, when one allele induces a heritable mutation in another allele without modifying the DNA sequence; now, in Drosophila, a paramutation is shown to be transmissible over generations.

Date: 2012
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DOI: 10.1038/nature11416

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