Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

Jared H. Rowe, James M. Ertelt, Lijun Xin and Sing Sing Way ()
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Jared H. Rowe: University of Minnesota School of Medicine, Center for Infectious Disease and Microbiology Translational Research, Center for Immunology
James M. Ertelt: University of Minnesota School of Medicine, Center for Infectious Disease and Microbiology Translational Research, Center for Immunology
Lijun Xin: University of Minnesota School of Medicine, Center for Infectious Disease and Microbiology Translational Research, Center for Immunology
Sing Sing Way: University of Minnesota School of Medicine, Center for Infectious Disease and Microbiology Translational Research, Center for Immunology

Nature, 2012, vol. 490, issue 7418, 102-106

Abstract: Successful pregnancy requires immune tolerance against paternal antigens expressed by the fetus; here pregnancy is shown to stimulate the selective accumulation of maternal immune-suppressive regulatory T cells with fetal specificity that are retained post-partum, which may explain the protective benefits of prior pregnancy against pre-eclampsia and other complications in subsequent pregnancy.

Date: 2012
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DOI: 10.1038/nature11462

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