HIV-infected T cells are migratory vehicles for viral dissemination

Thomas T. Murooka, Maud Deruaz, Francesco Marangoni, Vladimir D. Vrbanac, Edward Seung, Ulrich H. von Andrian, Andrew M. Tager, Andrew D. Luster and Thorsten R. Mempel ()
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Thomas T. Murooka: The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School
Maud Deruaz: The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School
Francesco Marangoni: The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School
Vladimir D. Vrbanac: The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School
Edward Seung: The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School
Ulrich H. von Andrian: Harvard Medical School
Andrew M. Tager: The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School
Andrew D. Luster: The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School
Thorsten R. Mempel: The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School

Nature, 2012, vol. 490, issue 7419, 283-287

Abstract: Using intravital microscopy, this study visualizes HIV-1-infected T cells within the lymph nodes of humanized mice, demonstrating that infected cells have reduced motility and long membrane processes; treating infected mice with a lymphocyte egress inhibitor prevents HIV-1 from spreading to the circulation during the course of treatment.

Date: 2012
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DOI: 10.1038/nature11398

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