Restoration of auditory evoked responses by human ES-cell-derived otic progenitors

Wei Chen, Nopporn Jongkamonwiwat, Leila Abbas, Sarah Jacob Eshtan, Stuart L. Johnson, Stephanie Kuhn, Marta Milo, Johanna K. Thurlow, Peter W. Andrews, Walter Marcotti, Harry D. Moore and Marcelo N. Rivolta ()
Additional contact information
Wei Chen: Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
Nopporn Jongkamonwiwat: Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
Leila Abbas: Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
Sarah Jacob Eshtan: Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
Stuart L. Johnson: University of Sheffield, Sheffield S10 2TN, UK
Stephanie Kuhn: University of Sheffield, Sheffield S10 2TN, UK
Marta Milo: University of Sheffield, Sheffield S10 2TN, UK
Johanna K. Thurlow: Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
Peter W. Andrews: Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
Walter Marcotti: University of Sheffield, Sheffield S10 2TN, UK
Harry D. Moore: Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK
Marcelo N. Rivolta: Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK

Nature, 2012, vol. 490, issue 7419, 278-282

Abstract: Two types of human ES-cell-derived otic progenitors are shown to have the ability to differentiate in vitro into hair-cell-like cells and auditory neurons, and to engraft, differentiate and improve auditory-evoked response thresholds when transplanted into an auditory neuropathy model; this indicates that it may be possible to use cell-based therapeutic strategies to recover damaged sensory circuitry in deafness.

Date: 2012
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DOI: 10.1038/nature11415

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