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Dopaminergic neurons inhibit striatal output through non-canonical release of GABA

Nicolas X. Tritsch, Jun B. Ding and Bernardo L. Sabatini ()
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Nicolas X. Tritsch: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Jun B. Ding: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Bernardo L. Sabatini: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA

Nature, 2012, vol. 490, issue 7419, 262-266

Abstract: Activation of midbrain dopamine neurons rapidly inhibits action potential firing in both direct- and indirect-pathway striatal projection neurons through VMAT2-dependent vesicular release of the inhibitory transmitter GABA (γ-aminobutyric acid).

Date: 2012
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DOI: 10.1038/nature11466

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