A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses

Vladimir Litvak, Alexander V. Ratushny, Aaron E. Lampano, Frank Schmitz, Albert C. Huang, Ayush Raman, Alistair G. Rust, Andreas Bergthaler, John D. Aitchison and Alan Aderem ()
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Vladimir Litvak: Seattle Biomedical Research Institute
Alexander V. Ratushny: Seattle Biomedical Research Institute
Aaron E. Lampano: Seattle Biomedical Research Institute
Frank Schmitz: Seattle Biomedical Research Institute
Albert C. Huang: Institute for Systems Biology
Ayush Raman: Institute for Systems Biology
Alistair G. Rust: Experimental Cancer Genetics, Welcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Andreas Bergthaler: Research Center for Molecular Medicine, Austrian Academy of Sciences, Lazarettgasse 14 AKH BT 25.3, 1090 Vienna, Austria
John D. Aitchison: Seattle Biomedical Research Institute
Alan Aderem: Seattle Biomedical Research Institute

Nature, 2012, vol. 490, issue 7420, 421-425

Abstract: FOXO3 is a negative regulator of IRF7, a master regulator of the antiviral response.

Date: 2012
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DOI: 10.1038/nature11428

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