Initiation of transcription-coupled repair characterized at single-molecule resolution

Kévin Howan, Abigail J. Smith, Lars F. Westblade, Nicolas Joly, Wilfried Grange, Sylvain Zorman, Seth A. Darst, Nigel J. Savery and Terence R. Strick ()
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Kévin Howan: Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité F-75205 Paris, France
Abigail J. Smith: DNA-Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
Lars F. Westblade: The Rockefeller University, 1230 York Avenue
Nicolas Joly: Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité F-75205 Paris, France
Wilfried Grange: Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité F-75205 Paris, France
Sylvain Zorman: Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité F-75205 Paris, France
Seth A. Darst: The Rockefeller University, 1230 York Avenue
Nigel J. Savery: DNA-Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
Terence R. Strick: Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité F-75205 Paris, France

Nature, 2012, vol. 490, issue 7420, 431-434

Abstract: The early stages of transcription-coupled DNA repair are observed at single-molecule resolution; the Escherichia coli DNA translocase molecule Mfd is shown to promote RNA polymerase dissociation by catalysing two irreversible, ATP-dependent transitions.

Date: 2012
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DOI: 10.1038/nature11430

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