Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive

Julia C. Lemos, Matthew J. Wanat, Jeffrey S. Smith, Beverly A. S. Reyes, Nick G. Hollon, Elisabeth J. Van Bockstaele, Charles Chavkin and Paul E. M. Phillips ()
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Julia C. Lemos: University of Washington
Matthew J. Wanat: University of Washington
Jeffrey S. Smith: University of Washington
Beverly A. S. Reyes: Farber Institute for Neurosciences, Thomas Jefferson University
Nick G. Hollon: University of Washington
Elisabeth J. Van Bockstaele: Farber Institute for Neurosciences, Thomas Jefferson University
Charles Chavkin: University of Washington
Paul E. M. Phillips: University of Washington

Nature, 2012, vol. 490, issue 7420, 402-406

Abstract: The neuropeptide corticotropin-releasing factor (CRF) acts in the nucleus accumbens of mice to increase dopamine release through coactivation of CRF receptor 1 (CRFR1) and CRFR2, but exposure to severe stress results in loss of this regulation and a switch in the reaction to CRF from appetitive to aversive.

Date: 2012
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DOI: 10.1038/nature11436

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