Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

Rolland, Morgane; Edlefsen, Paul T.; Larsen, Brendan B.; Tovanabutra, Sodsai; Sanders-Buell, Eric; Hertz, Tomer; deCamp, Allan C.; Carrico, Chris; Menis, Sergey; Magaret, Craig A.; Ahmed, Hasan; Juraska, Michal; Chen, Lennie; Konopa, Philip; Nariya, Snehal; Stoddard, Julia N.; Wong, Kim; Zhao, Hong; Deng, Wenjie; Maust, Brandon S.; Bose, Meera; Howell, Shana; Bates, Adam; Lazzaro, Michelle; O’Sullivan, Annemarie; Lei, Esther; Bradfield, Andrea; Ibitamuno, Grace; Assawadarachai, Vatcharain; O’Connell, Robert J.; deSouza, Mark S.; Nitayaphan, Sorachai; Rerks-Ngarm, Supachai; Robb, Merlin L.; McLellan, Jason S.; Georgiev, Ivelin; Kwong, Peter D.; Carlson, Jonathan M.; Michael, Nelson L.; Schief, William R.; Gilbert, Peter B.; Mullins, James I.; Kim, Jerome H.

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

Morgane Rolland (), Paul T. Edlefsen, Brendan B. Larsen, Sodsai Tovanabutra, Eric Sanders-Buell, Tomer Hertz, Allan C. deCamp, Chris Carrico, Sergey Menis, Craig A. Magaret, Hasan Ahmed, Michal Juraska, Lennie Chen, Philip Konopa, Snehal Nariya, Julia N. Stoddard, Kim Wong, Hong Zhao, Wenjie Deng, Brandon S. Maust, Meera Bose, Shana Howell, Adam Bates, Michelle Lazzaro, Annemarie O’Sullivan, Esther Lei, Andrea Bradfield, Grace Ibitamuno, Vatcharain Assawadarachai, Robert J. O’Connell, Mark S. deSouza, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Merlin L. Robb, Jason S. McLellan, Ivelin Georgiev, Peter D. Kwong, Jonathan M. Carlson, Nelson L. Michael, William R. Schief, Peter B. Gilbert, James I. Mullins and Jerome H. Kim
Additional contact information
Morgane Rolland: US Military HIV Research Program
Paul T. Edlefsen: Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center
Brendan B. Larsen: University of Washington
Sodsai Tovanabutra: US Military HIV Research Program
Eric Sanders-Buell: US Military HIV Research Program
Tomer Hertz: Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center
Allan C. deCamp: Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center
Chris Carrico: University of Washington
Sergey Menis: University of Washington
Craig A. Magaret: Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center
Hasan Ahmed: Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center
Michal Juraska: Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center
Lennie Chen: University of Washington
Philip Konopa: University of Washington
Snehal Nariya: University of Washington
Julia N. Stoddard: University of Washington
Kim Wong: University of Washington
Hong Zhao: University of Washington
Wenjie Deng: University of Washington
Brandon S. Maust: University of Washington
Meera Bose: US Military HIV Research Program
Shana Howell: US Military HIV Research Program
Adam Bates: US Military HIV Research Program
Michelle Lazzaro: US Military HIV Research Program
Annemarie O’Sullivan: US Military HIV Research Program
Esther Lei: US Military HIV Research Program
Andrea Bradfield: US Military HIV Research Program
Grace Ibitamuno: US Military HIV Research Program
Vatcharain Assawadarachai: Royal Thai Army Component, AFRIMS, Bangkok 10400, Thailand
Robert J. O’Connell: US Military HIV Research Program
Mark S. deSouza: Royal Thai Army Component, AFRIMS, Bangkok 10400, Thailand
Sorachai Nitayaphan: Royal Thai Army Component, AFRIMS, Bangkok 10400, Thailand
Supachai Rerks-Ngarm: Thai Ministry of Public Health, Nonthaburi 11000, Thailand
Merlin L. Robb: US Military HIV Research Program
Jason S. McLellan: Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
Ivelin Georgiev: Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
Peter D. Kwong: Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
Jonathan M. Carlson: Microsoft Research
Nelson L. Michael: US Military HIV Research Program
William R. Schief: University of Washington
Peter B. Gilbert: Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center
James I. Mullins: University of Washington
Jerome H. Kim: US Military HIV Research Program

Nature, 2012, vol. 490, issue 7420, 417-420

Abstract: Genetic analysis of breakthrough infections in people vaccinated against HIV-1 show that vaccine efficacy increased by up to 80% against viruses carrying two mutations in Env V2, but also raises the possibility of population-level adaptation to the vaccine.

Date: 2012
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DOI: 10.1038/nature11519

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