The inner life of proteins

Günter P. Wagner ()
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Günter P. Wagner: and at the Yale Systems Biology Institute, Yale University, New Haven, Connecticut 06477, USA.

Nature, 2012, vol. 490, issue 7421, 493-494

Abstract: A quantitative analysis shows that epistasis — the fact that genetic background determines whether a mutation is beneficial, deleterious or inconsequential — is the main factor regulating evolution at the level of proteins. See Letter p.535

Date: 2012
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DOI: 10.1038/490493a

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