Phosphorylation of NLRC4 is critical for inflammasome activation

Yan Qu, Shahram Misaghi, Anita Izrael-Tomasevic, Kim Newton, Laurie L. Gilmour, Mohamed Lamkanfi, Salina Louie, Nobuhiko Kayagaki, Jinfeng Liu, László Kömüves, James E. Cupp, David Arnott, Denise Monack and Vishva M. Dixit ()
Additional contact information
Yan Qu: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Shahram Misaghi: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Anita Izrael-Tomasevic: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Kim Newton: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Laurie L. Gilmour: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Mohamed Lamkanfi: VIB, B-9000 Ghent, Belgium
Salina Louie: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Nobuhiko Kayagaki: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jinfeng Liu: 1 DNA Way
László Kömüves: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
James E. Cupp: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
David Arnott: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Denise Monack: Stanford School of Medicine
Vishva M. Dixit: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA

Nature, 2012, vol. 490, issue 7421, 539-542

Abstract: Phosphorylation of the NOD-like receptor NLRC4 is essential for activation of the NLRC4 inflammasome complex in response to bacterial stimuli.

Date: 2012
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DOI: 10.1038/nature11429

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