Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

Mi Sun Jin, Michael L. Oldham, Qiuju Zhang and Jue Chen ()
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Mi Sun Jin: Purdue University
Michael L. Oldham: Howard Hughes Medical Institute
Qiuju Zhang: Howard Hughes Medical Institute
Jue Chen: Purdue University

Nature, 2012, vol. 490, issue 7421, 566-569

Abstract: Biochemical and structural analysis of the drug transporter P-glycoprotein in Caenorhabditis elegans at a resolution of 3.4 angstroms is used to generate a homology model of the human protein and supports a picture in which P-glycoprotein uses the energy from ATP hydrolysis to expel lipophilic molecules from the inner leaflet of the cell membrane.

Date: 2012
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DOI: 10.1038/nature11448

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