Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila

Shizue Ohsawa, Yoshitaka Sato, Masato Enomoto, Mai Nakamura, Aya Betsumiya and Tatsushi Igaki ()
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Shizue Ohsawa: Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Yoshitaka Sato: Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Masato Enomoto: Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Mai Nakamura: Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Aya Betsumiya: Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Tatsushi Igaki: Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

Nature, 2012, vol. 490, issue 7421, 547-551

Abstract: In a Drosophila imaginal epithelial disc system, mutations that lead to mitochondrial dysfunction can also promote tumorigenic growth of neighbouring cells expressing an activated Ras oncogene.

Date: 2012
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DOI: 10.1038/nature11452

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