Black mamba venom peptides target acid-sensing ion channels to abolish pain

Sylvie Diochot, Anne Baron (), Miguel Salinas, Dominique Douguet, Sabine Scarzello, Anne-Sophie Dabert-Gay, Delphine Debayle, Valérie Friend, Abdelkrim Alloui, Michel Lazdunski and Eric Lingueglia ()
Additional contact information
Sylvie Diochot: CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
Anne Baron: CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
Miguel Salinas: CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
Dominique Douguet: CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
Sabine Scarzello: CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
Anne-Sophie Dabert-Gay: CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
Delphine Debayle: CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
Valérie Friend: CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
Abdelkrim Alloui: Clermont Université, Université d’Auvergne, NEURO-DOL, BP 10448, F-63000 Clermont-Ferrand, France
Michel Lazdunski: CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
Eric Lingueglia: CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France

Nature, 2012, vol. 490, issue 7421, 552-555

Abstract: A new class of peptides, mambalgins, is isolated from the African snake the black mamba, which can abolish pain through inhibition of particular subtypes of acid-sensing ion channels expressed either in central or peripheral neurons.

Date: 2012
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DOI: 10.1038/nature11494

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