Clonal allelic predetermination of immunoglobulin-κ rearrangement

Marganit Farago, Chaggai Rosenbluh, Maya Tevlin, Shira Fraenkel, Sharon Schlesinger, Hagit Masika, Masha Gouzman, Grace Teng, David Schatz, Yoach Rais, Jacob H. Hanna, Alexander Mildner, Steffen Jung, Gustavo Mostoslavsky, Howard Cedar () and Yehudit Bergman ()
Additional contact information
Marganit Farago: Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel
Chaggai Rosenbluh: Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel
Maya Tevlin: Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel
Shira Fraenkel: Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel
Sharon Schlesinger: Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel
Hagit Masika: Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel
Masha Gouzman: Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel
Grace Teng: Yale University School of Medicine, 300 Cedar Street, PO Box 208011, New Haven, Connecticut 06520, USA
David Schatz: Yale University School of Medicine, 300 Cedar Street, PO Box 208011, New Haven, Connecticut 06520, USA
Yoach Rais: Weizmann Institute of Science
Jacob H. Hanna: Weizmann Institute of Science
Alexander Mildner: Weizmann Institute of Science
Steffen Jung: Weizmann Institute of Science
Gustavo Mostoslavsky: Center for Regenerative Medicine (CReM), Boston University School of Medicine, 650 Albany Street, Suite 513, Boston, Massachusetts 02118, USA
Howard Cedar: Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel
Yehudit Bergman: Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel

Nature, 2012, vol. 490, issue 7421, 561-565

Abstract: Immunoglobulin genes are expressed from either the maternal or paternal chromosome; it is now shown that in early haematopoietic stem cells, an individual cell can choose either of the two alleles, but as they develop they become committed to only one.

Date: 2012
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DOI: 10.1038/nature11496

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