Epistasis as the primary factor in molecular evolution

Michael S. Breen, Carsten Kemena, Peter K. Vlasov, Cedric Notredame and Fyodor A. Kondrashov ()
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Michael S. Breen: Bioinformatics and Genomics Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, 88 Dr Aiguader, Barcelona 08003, Spain
Carsten Kemena: Bioinformatics and Genomics Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, 88 Dr Aiguader, Barcelona 08003, Spain
Peter K. Vlasov: Bioinformatics and Genomics Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, 88 Dr Aiguader, Barcelona 08003, Spain
Cedric Notredame: Bioinformatics and Genomics Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, 88 Dr Aiguader, Barcelona 08003, Spain
Fyodor A. Kondrashov: Bioinformatics and Genomics Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, 88 Dr Aiguader, Barcelona 08003, Spain

Nature, 2012, vol. 490, issue 7421, 535-538

Abstract: A comparison of more than 1,000 orthologues of diverse proteins shows that the rate of amino-acid substitution in recent evolution is an order of magnitude lower than that expected in the absence of epistasis, indicating that epistasis is pervasive throughout protein evolution.

Date: 2012
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DOI: 10.1038/nature11510

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