Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

Manqing Li, Elaine Kao, Xia Gao, Hilary Sandig, Kirsten Limmer, Mariana Pavon-Eternod, Thomas E. Jones, Sebastien Landry, Tao Pan, Matthew D. Weitzman and Michael David ()
Additional contact information
Manqing Li: Section of Molecular Biology, University of California San Diego
Elaine Kao: Section of Molecular Biology, University of California San Diego
Xia Gao: Section of Molecular Biology, University of California San Diego
Hilary Sandig: Section of Molecular Biology, University of California San Diego
Kirsten Limmer: Section of Molecular Biology, University of California San Diego
Mariana Pavon-Eternod: University of Chicago
Thomas E. Jones: University of Chicago
Sebastien Landry: Laboratory of Genetics, The Salk Institute for Biological Studies
Tao Pan: University of Chicago
Matthew D. Weitzman: Laboratory of Genetics, The Salk Institute for Biological Studies
Michael David: Section of Molecular Biology, University of California San Diego

Nature, 2012, vol. 491, issue 7422, 125-128

Abstract: Schlafen proteins are produced in response to interferon signalling, which can be activated by retroviral infection; this study shows that human schlafen 11 inhibits the late stages of HIV-1 production by binding non-specifically to tRNAs, thus preventing the expression of viral proteins.

Date: 2012
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature11433 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:491:y:2012:i:7422:d:10.1038_nature11433

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature11433

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().