Vaccine-induced CD8+ T cells control AIDS virus replication

Philip A. Mudd, Mauricio A. Martins, Adam J. Ericsen, Damien C. Tully, Karen A. Power, Alex T. Bean, Shari M. Piaskowski, Lijie Duan, Aaron Seese, Adrianne D. Gladden, Kim L. Weisgrau, Jessica R. Furlott, Young-il Kim, Marlon G. Veloso de Santana, Eva Rakasz, Saverio Capuano, Nancy A. Wilson, Myrna C. Bonaldo, Ricardo Galler, David B. Allison, Michael Piatak, Ashley T. Haase, Jeffrey D. Lifson, Todd M. Allen and David I. Watkins ()
Additional contact information
Philip A. Mudd: University of Wisconsin-Madison
Mauricio A. Martins: University of Miami Miller School of Medicine
Adam J. Ericsen: University of Wisconsin-Madison
Damien C. Tully: Ragon Institute of MGH, MIT and Harvard
Karen A. Power: Ragon Institute of MGH, MIT and Harvard
Alex T. Bean: University of Wisconsin-Madison
Shari M. Piaskowski: University of Wisconsin-Madison
Lijie Duan: University of Minnesota
Aaron Seese: Ragon Institute of MGH, MIT and Harvard
Adrianne D. Gladden: Ragon Institute of MGH, MIT and Harvard
Kim L. Weisgrau: University of Wisconsin-Madison
Jessica R. Furlott: University of Wisconsin-Madison
Young-il Kim: University of Alabama at Birmingham
Marlon G. Veloso de Santana: Laboratório de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz—FIOCRUZ, Rio de Janeiro, Brazil
Eva Rakasz: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Saverio Capuano: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Nancy A. Wilson: University of Wisconsin-Madison
Myrna C. Bonaldo: Laboratório de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz—FIOCRUZ, Rio de Janeiro, Brazil
Ricardo Galler: Instituto de Tecnologia em Imunobiológicos, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
David B. Allison: Section on Statistical Genetics, University of Alabama at Birmingham
Michael Piatak: AIDS and Cancer Virus Program, SAIC Frederick, Inc., National Cancer Institute
Ashley T. Haase: University of Minnesota
Jeffrey D. Lifson: AIDS and Cancer Virus Program, SAIC Frederick, Inc., National Cancer Institute
Todd M. Allen: Ragon Institute of MGH, MIT and Harvard
David I. Watkins: University of Miami Miller School of Medicine

Nature, 2012, vol. 491, issue 7422, 129-133

Abstract: Indian rhesus macaques are vaccinated with simian immunodeficiency virus (SIV)-restricted CD8+ T-cell epitopes, and these vaccinated animals are shown to mediate elite control of virus replication.

Date: 2012
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DOI: 10.1038/nature11443

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