The spatial architecture of protein function and adaptation

Richard N. McLaughlin, Frank J. Poelwijk, Arjun Raman, Walraj S. Gosal and Rama Ranganathan ()
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Richard N. McLaughlin: Green Center for Systems Biology, University of Texas Southwestern Medical Center
Frank J. Poelwijk: Green Center for Systems Biology, University of Texas Southwestern Medical Center
Arjun Raman: Green Center for Systems Biology, University of Texas Southwestern Medical Center
Walraj S. Gosal: Green Center for Systems Biology, University of Texas Southwestern Medical Center
Rama Ranganathan: Green Center for Systems Biology, University of Texas Southwestern Medical Center

Nature, 2012, vol. 491, issue 7422, 138-142

Abstract: A high-throughput mutagenesis study in a PDZ domain shows that biochemical function and adaptation primarily originate from a collectively evolving amino acid network within the structure termed a protein sector.

Date: 2012
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DOI: 10.1038/nature11500

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