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The molecular basis of phosphate discrimination in arsenate-rich environments

Mikael Elias (), Alon Wellner, Korina Goldin-Azulay, Eric Chabriere, Julia A. Vorholt, Tobias J. Erb and Dan S. Tawfik ()
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Mikael Elias: Weizmann Institute of Science
Alon Wellner: Weizmann Institute of Science
Korina Goldin-Azulay: Weizmann Institute of Science
Eric Chabriere: Unité de recherche sur les maladies infectieuses et tropicales émergentes, Faculté de Médecine et de Pharmacie, CNRS-Université de la Méditerranée, 13385 Marseille, France
Julia A. Vorholt: Institute of Microbiology, Eidgenössische Technische Hochschule Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
Tobias J. Erb: Institute of Microbiology, Eidgenössische Technische Hochschule Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
Dan S. Tawfik: Weizmann Institute of Science

Nature, 2012, vol. 491, issue 7422, 134-137

Abstract: Ultrahigh-resolution X-ray crystallography study of a phosphate-binding protein from Pseudomonas fluorescens yields insight into how phosphate ions essential for life are discriminated from the arsenate ions inimical to it, even in arsenate-rich environments.

Date: 2012
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DOI: 10.1038/nature11517

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