In vivo genome editing using a high-efficiency TALEN system

Victoria M. Bedell, Ying Wang, Jarryd M. Campbell, Tanya L. Poshusta, Colby G. Starker, Randall G. Krug, Wenfang Tan, Sumedha G. Penheiter, Alvin C. Ma, Anskar Y. H. Leung, Scott C. Fahrenkrug, Daniel F. Carlson, Daniel F. Voytas, Karl J. Clark, Jeffrey J. Essner and Stephen C. Ekker ()
Additional contact information
Victoria M. Bedell: Mayo Clinic
Ying Wang: Development and Cell Biology, Iowa State University
Jarryd M. Campbell: Mayo Clinic
Tanya L. Poshusta: Mayo Clinic
Colby G. Starker: Cell Biology and Development, the Center for Genome Engineering, University of Minnesota
Randall G. Krug: Mayo Clinic
Wenfang Tan: Cell Biology and Development, the Center for Genome Engineering, University of Minnesota
Sumedha G. Penheiter: Mayo Clinic
Alvin C. Ma: Mayo Clinic
Anskar Y. H. Leung: LKS Faculty of Medicine, the University of Hong Kong, Pok Fu Lam Road, Hong Kong
Scott C. Fahrenkrug: Cell Biology and Development, the Center for Genome Engineering, University of Minnesota
Daniel F. Carlson: Cell Biology and Development, the Center for Genome Engineering, University of Minnesota
Daniel F. Voytas: Cell Biology and Development, the Center for Genome Engineering, University of Minnesota
Karl J. Clark: Mayo Clinic
Jeffrey J. Essner: Development and Cell Biology, Iowa State University
Stephen C. Ekker: Mayo Clinic

Nature, 2012, vol. 491, issue 7422, 114-118

Abstract: Although zebrafish is an important animal model for basic vertebrate biology and human disease modelling, rapid targeted genome modification has not been possible in this species; here a technique based on improved artificial transcription activator-like effector nucleases (TALENs) allows precise sequence modifications at pre-determined genomic locations.

Date: 2012
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DOI: 10.1038/nature11537

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