Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Luke Jostins, Stephan Ripke, Rinse K. Weersma, Richard H. Duerr, Dermot P. McGovern, Ken Y. Hui, James C. Lee, L. Philip Schumm, Yashoda Sharma, Carl A. Anderson, Jonah Essers, Mitja Mitrovic, Kaida Ning, Isabelle Cleynen, Emilie Theatre, Sarah L. Spain, Soumya Raychaudhuri, Philippe Goyette, Zhi Wei, Clara Abraham, Jean-Paul Achkar, Tariq Ahmad, Leila Amininejad, Ashwin N. Ananthakrishnan, Vibeke Andersen, Jane M. Andrews, Leonard Baidoo, Tobias Balschun, Peter A. Bampton, Alain Bitton, Gabrielle Boucher, Stephan Brand, Carsten Büning, Ariella Cohain, Sven Cichon, Mauro D’Amato, Dirk De Jong, Kathy L. Devaney, Marla Dubinsky, Cathryn Edwards, David Ellinghaus, Lynnette R. Ferguson, Denis Franchimont, Karin Fransen, Richard Gearry, Michel Georges, Christian Gieger, Jürgen Glas, Talin Haritunians, Ailsa Hart, Chris Hawkey, Matija Hedl, Xinli Hu, Tom H. Karlsen, Limas Kupcinskas, Subra Kugathasan, Anna Latiano, Debby Laukens, Ian C. Lawrance, Charlie W. Lees, Edouard Louis, Gillian Mahy, John Mansfield, Angharad R. Morgan, Craig Mowat, William Newman, Orazio Palmieri, Cyriel Y. Ponsioen, Uros Potocnik, Natalie J. Prescott, Miguel Regueiro, Jerome I. Rotter, Richard K. Russell, Jeremy D. Sanderson, Miquel Sans, Jack Satsangi, Stefan Schreiber, Lisa A. Simms, Jurgita Sventoraityte, Stephan R. Targan, Kent D. Taylor, Mark Tremelling, Hein W. Verspaget, Martine De Vos, Cisca Wijmenga, David C. Wilson, Juliane Winkelmann, Ramnik J. Xavier, Sebastian Zeissig, Bin Zhang, Clarence K. Zhang, Hongyu Zhao, Mark S. Silverberg, Vito Annese, Hakon Hakonarson, Steven R. Brant, Graham Radford-Smith, Christopher G. Mathew, John D. Rioux, Eric E. Schadt, Mark J. Daly, Andre Franke, Miles Parkes, Severine Vermeire, Jeffrey C. Barrett and Judy H Cho ()
Additional contact information
Luke Jostins: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Stephan Ripke: Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School
Rinse K. Weersma: University of Groningen and University Medical Center Groningen, Groningen 9700 RB, The Netherlands.
Richard H. Duerr: Hepatology and Nutrition, University of Pittsburgh School of Medicine
Dermot P. McGovern: F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute
Ken Y. Hui: Yale School of Medicine, New Haven, Connecticut 06520, USA.
James C. Lee: Inflammatory Bowel Disease Research Group, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.
L. Philip Schumm: University of Chicago
Yashoda Sharma: Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut 06520, USA.
Carl A. Anderson: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Jonah Essers: Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School
Mitja Mitrovic: University of Maribor, Faculty of Medicine, Center for Human Molecular Genetics and Pharmacogenomics, Maribor 2000, Slovenia.
Kaida Ning: Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut 06520, USA.
Isabelle Cleynen: Gastroenterology section, KU Leuven, Leuven 3000, Belgium.
Emilie Theatre: Unit of Animal Genomics, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-R) and Faculty of Veterinary Medicine, University of Liège, Liège 4000, Belgium.
Sarah L. Spain: King’s College London School of Medicine, Guy’s Hospital, London SE1 9RT, UK.
Soumya Raychaudhuri: Brigham and Women’s Hospital
Philippe Goyette: Université de Montréal and the Montreal Heart Institute, Research Center, Montréal, Québec H1T 1C8, Canada.
Zhi Wei: New Jersey Institute of Technology, Newark, New Jersey 07102, USA.
Clara Abraham: Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut 06520, USA.
Jean-Paul Achkar: Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Tariq Ahmad: Peninsula College of Medicine and Dentistry, Exeter EX1 2LU, UK.
Leila Amininejad: Erasmus Hospital, Free University of Brussels, Brussels, 1070 Belgium.
Ashwin N. Ananthakrishnan: Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit
Vibeke Andersen: Viborg Regional Hospital, Viborg 8800, Denmark.
Jane M. Andrews: Inflammatory Bowel Disease Service, Royal Adelaide Hospital, and School of Medicine, University of Adelaide, Adelaide 5000, Australia.
Leonard Baidoo: Hepatology and Nutrition, University of Pittsburgh School of Medicine
Tobias Balschun: Institute of Clinical Chemistry, Christian-Albrechts-University, Kiel 24105, Germany.
Peter A. Bampton: Flinders Medical Centre and School of Medicine, Flinders University, Adelaide 5000, Australia.
Alain Bitton: McGill University Health Centre, Royal Victoria Hospital, Montréal, Québec H3A 1A1, Canada.
Gabrielle Boucher: Université de Montréal and the Montreal Heart Institute, Research Center, Montréal, Québec H1T 1C8, Canada.
Stephan Brand: University Hospital Munich-Grosshadern, Ludwig-Maximilians-University, Munich 80336, Germany.
Carsten Büning: Charité, Campus Mitte, Universitätsmedizin Berlin, Berlin 10117, Germany.
Ariella Cohain: Mount Sinai School of Medicine
Sven Cichon: Life & Brain Center, University Hospital Bonn, Bonn 53012, Germany.
Mauro D’Amato: Karolinska Institutet, Stockholm 14 183, Sweden.
Dirk De Jong: University of Groningen and University Medical Center Groningen, Groningen 9700 RB, The Netherlands.
Kathy L. Devaney: Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit
Marla Dubinsky: Cedars Sinai Medical Center
Cathryn Edwards: Torbay Hospital, Torbay, Devon TQ2 7AA, UK.
David Ellinghaus: Institute of Clinical Chemistry, Christian-Albrechts-University, Kiel 24105, Germany.
Lynnette R. Ferguson: School of Medical Sciences, Faculty of Medical & Health Sciences, The University of Auckland, Auckland 1142, New Zealand.
Denis Franchimont: Erasmus Hospital, Free University of Brussels, Brussels, 1070 Belgium.
Karin Fransen: Hepatology and Nutrition, University of Pittsburgh School of Medicine
Richard Gearry: University of Otago, Christchurch 8140, New Zealand.
Michel Georges: Unit of Animal Genomics, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-R) and Faculty of Veterinary Medicine, University of Liège, Liège 4000, Belgium.
Christian Gieger: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.
Jürgen Glas: McGill University Health Centre, Royal Victoria Hospital, Montréal, Québec H3A 1A1, Canada.
Talin Haritunians: Medical Genetics Institute, Cedars-Sinai Medical Center
Ailsa Hart: St Mark’s Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK.
Chris Hawkey: Nottingham Digestive Diseases Centre, Queens Medical Centre, Nottingham NG7 1AW, UK.
Matija Hedl: Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut 06520, USA.
Xinli Hu: Brigham and Women’s Hospital
Tom H. Karlsen: Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo 0424, Norway.
Limas Kupcinskas: Kaunas University of Medicine, Kaunas 44307, Lithuania.
Subra Kugathasan: Emory University School of Medicine
Anna Latiano: Unit of Gastroenterology, Istituto di Ricovero e Cura a Carattere Scientifico-Casa Sollievo della Sofferenza (IRCCS-CSS) Hospital, San Giovanni Rotondo 71013, Italy.
Debby Laukens: Ghent University Hospital, Ghent 9000, Belgium.
Ian C. Lawrance: School of Medicine and Pharmacology, The University of Western Australia, Fremantle, Western Australia 6009, Australia.
Charlie W. Lees: Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Edouard Louis: Centre Hospitalier Universitaire, Université de Liège, Liège 4000, Belgium.
Gillian Mahy: The Townsville Hospital
John Mansfield: Institute of Human Genetics, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Angharad R. Morgan: School of Medical Sciences, Faculty of Medical & Health Sciences, The University of Auckland, Auckland 1142, New Zealand.
Craig Mowat: Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
William Newman: Genetic Medicine, MAHSC, University of Manchester, Manchester M13 9PL, UK.
Orazio Palmieri: Unit of Gastroenterology, Istituto di Ricovero e Cura a Carattere Scientifico-Casa Sollievo della Sofferenza (IRCCS-CSS) Hospital, San Giovanni Rotondo 71013, Italy.
Cyriel Y. Ponsioen: Academic Medical Center, Amsterdam 1105 AZ, The Netherlands.
Uros Potocnik: University of Maribor, Faculty of Medicine, Center for Human Molecular Genetics and Pharmacogenomics, Maribor 2000, Slovenia.
Natalie J. Prescott: King’s College London School of Medicine, Guy’s Hospital, London SE1 9RT, UK.
Miguel Regueiro: Hepatology and Nutrition, University of Pittsburgh School of Medicine
Jerome I. Rotter: Medical Genetics Institute, Cedars-Sinai Medical Center
Richard K. Russell: Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow G3 8SJ, UK.
Jeremy D. Sanderson: Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, London SE1 7EH, UK.
Miquel Sans: Hospital Clinic/Institut d’Investigacions Biomédiques August Pi i Sunyer (IDIBAPS)
Jack Satsangi: Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Stefan Schreiber: Institute of Clinical Chemistry, Christian-Albrechts-University, Kiel 24105, Germany.
Lisa A. Simms: Inflammatory Bowel Diseases, Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane 4029, Australia.
Jurgita Sventoraityte: Kaunas University of Medicine, Kaunas 44307, Lithuania.
Stephan R. Targan: F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute
Kent D. Taylor: F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute
Mark Tremelling: Norfolk and Norwich University Hospital, Norwich NR4 7UY, UK.
Hein W. Verspaget: Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Martine De Vos: Ghent University Hospital, Ghent 9000, Belgium.
Cisca Wijmenga: University of Groningen, University Medical Center Groningen, Groningen T9700 RB, The Netherlands.
David C. Wilson: Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow G3 8SJ, UK.
Juliane Winkelmann: Technische Universität München, Munich 80336, Germany.
Ramnik J. Xavier: Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit
Sebastian Zeissig: Christian-Albrechts-University, Kiel, Kiel 24118, Germany.
Bin Zhang: Mount Sinai School of Medicine
Clarence K. Zhang: School of Public Health, Yale University, New Haven, Connecticut 06520, USA.
Hongyu Zhao: School of Public Health, Yale University, New Haven, Connecticut 06520, USA.
Mark S. Silverberg: Mount Sinai Hospital Inflammatory Bowel Disease Centre, University of Toronto, Toronto, Ontario M5G 1X5, Canada.
Vito Annese: Unit of Gastroenterology, Istituto di Ricovero e Cura a Carattere Scientifico-Casa Sollievo della Sofferenza (IRCCS-CSS) Hospital, San Giovanni Rotondo 71013, Italy.
Hakon Hakonarson: Center for Applied Genomics, The Children’s Hospital of Philadelphia
Steven R. Brant: Meyerhoff Inflammatory Bowel Disease Center, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University
Graham Radford-Smith: Inflammatory Bowel Diseases, Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane 4029, Australia.
Christopher G. Mathew: King’s College London School of Medicine, Guy’s Hospital, London SE1 9RT, UK.
John D. Rioux: Université de Montréal and the Montreal Heart Institute, Research Center, Montréal, Québec H1T 1C8, Canada.
Eric E. Schadt: Mount Sinai School of Medicine
Mark J. Daly: Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School
Andre Franke: Institute of Clinical Chemistry, Christian-Albrechts-University, Kiel 24105, Germany.
Miles Parkes: Inflammatory Bowel Disease Research Group, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.
Severine Vermeire: Gastroenterology section, KU Leuven, Leuven 3000, Belgium.
Jeffrey C. Barrett: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Judy H Cho: Yale School of Medicine, New Haven, Connecticut 06520, USA.

Nature, 2012, vol. 491, issue 7422, 119-124

Abstract: A meta-analysis of previous genome-wide association studies of Crohn’s disease and ulcerative colitis, the two most common forms of inflammatory bowel disease, with a combined total of more than 75,000 cases and controls, finds that most loci contribute to both phenotypes and other immune-mediated disorders.

Date: 2012
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DOI: 10.1038/nature11582

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