Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Sergei I. Grivennikov, Kepeng Wang, Daniel Mucida, C. Andrew Stewart, Bernd Schnabl, Dominik Jauch, Koji Taniguchi, Guann-Yi Yu, Christoph H. Österreicher, Kenneth E. Hung, Christian Datz, Ying Feng, Eric R. Fearon, Mohamed Oukka, Lino Tessarollo, Vincenzo Coppola, Felix Yarovinsky, Hilde Cheroutre, Lars Eckmann, Giorgio Trinchieri and Michael Karin ()
Additional contact information
Sergei I. Grivennikov: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
Kepeng Wang: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
Daniel Mucida: La Jolla Institute for Allergy and Immunology
C. Andrew Stewart: Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Bernd Schnabl: School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
Dominik Jauch: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
Koji Taniguchi: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
Guann-Yi Yu: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
Christoph H. Österreicher: School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
Kenneth E. Hung: Tufts Medical Center
Christian Datz: Oberndorf Hospital, Paracelsus Medical University
Ying Feng: Human Genetics and Pathology, University of Michigan Medical School
Eric R. Fearon: Human Genetics and Pathology, University of Michigan Medical School
Mohamed Oukka: Seattle Children’s Research Institute
Lino Tessarollo: Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health
Vincenzo Coppola: Immunology & Medical Genetics, Ohio State University Comprehensive Cancer Center, Wexner Medical Center
Felix Yarovinsky: University of Texas Southwestern Medical Center at Dallas
Hilde Cheroutre: La Jolla Institute for Allergy and Immunology
Lars Eckmann: School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
Giorgio Trinchieri: Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Michael Karin: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA

Nature, 2012, vol. 491, issue 7423, 254-258

Abstract: In a mouse model of colorectal cancer, barrier deterioration results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives IL-23-dependent tumour growth.

Date: 2012
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DOI: 10.1038/nature11465

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