The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

Jonathan J. Ipsaro, Astrid D. Haase, Simon R. Knott, Leemor Joshua-Tor () and Gregory J. Hannon ()
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Jonathan J. Ipsaro: W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory
Astrid D. Haase: Howard Hughes Medical Institute, Cold Spring Harbor Laboratory
Simon R. Knott: Howard Hughes Medical Institute, Cold Spring Harbor Laboratory
Leemor Joshua-Tor: W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory
Gregory J. Hannon: Howard Hughes Medical Institute, Cold Spring Harbor Laboratory

Nature, 2012, vol. 491, issue 7423, 279-283

Abstract: piRNAs act to protect the genome from the damaging effect of unrestrained expression of mobile elements; here it is suggested that the phosphodiesterase Zucchini may be the nuclease that generates the 5′ ends of primary piRNAs.

Date: 2012
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DOI: 10.1038/nature11502

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