Structure and function of Zucchini endoribonuclease in piRNA biogenesis

Hiroshi Nishimasu, Hirotsugu Ishizu, Kuniaki Saito, Satoshi Fukuhara, Miharu K. Kamatani, Luc Bonnefond, Naoki Matsumoto, Tomohiro Nishizawa, Keita Nakanaga, Junken Aoki, Ryuichiro Ishitani, Haruhiko Siomi, Mikiko C. Siomi () and Osamu Nureki ()
Additional contact information
Hiroshi Nishimasu: Graduate School of Science, The University of Tokyo
Hirotsugu Ishizu: Graduate School of Science, The University of Tokyo
Kuniaki Saito: Keio University School of Medicine
Satoshi Fukuhara: Graduate School of Science, The University of Tokyo
Miharu K. Kamatani: Keio University School of Medicine
Luc Bonnefond: Graduate School of Science, The University of Tokyo
Naoki Matsumoto: Graduate School of Science, The University of Tokyo
Tomohiro Nishizawa: Graduate School of Science, The University of Tokyo
Keita Nakanaga: Graduate School of Pharmaceutical Sciences, Tohoku University
Junken Aoki: Graduate School of Pharmaceutical Sciences, Tohoku University
Ryuichiro Ishitani: Graduate School of Science, The University of Tokyo
Haruhiko Siomi: Keio University School of Medicine
Mikiko C. Siomi: Graduate School of Science, The University of Tokyo
Osamu Nureki: Graduate School of Science, The University of Tokyo

Nature, 2012, vol. 491, issue 7423, 284-287

Abstract: Zucchini has been identified as an endoribonuclease responsible for the maturation of small RNA molecules that protect the genome from the damaging effects of unrestrained expression of mobile elements.

Date: 2012
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DOI: 10.1038/nature11509

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