Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA

Jason C. Bell, Jody L. Plank, Christopher C. Dombrowski and Stephen C. Kowalczykowski ()
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Jason C. Bell: University of California
Jody L. Plank: University of California
Christopher C. Dombrowski: University of California
Stephen C. Kowalczykowski: University of California

Nature, 2012, vol. 491, issue 7423, 274-278

Abstract: Single-molecule analysis of RecA filament assembly on its in vivo substrate, SSB-coated single-stranded DNA, reveals that a dimer of RecA is required for nucleation, and is followed by bidirectional growth of the filament through monomer addition; the recombination mediator RecOR accelerates nucleation and growth, and the addition of RecF further stimulates nucleation.

Date: 2012
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DOI: 10.1038/nature11598

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