A bimodular mechanism of calcium control in eukaryotes

Henning Tidow, Lisbeth R. Poulsen, Antonina Andreeva, Michael Knudsen, Kim L. Hein, Carsten Wiuf, Michael G. Palmgren () and Poul Nissen ()
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Henning Tidow: Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
Lisbeth R. Poulsen: Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
Antonina Andreeva: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Michael Knudsen: Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
Kim L. Hein: Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
Carsten Wiuf: University of Copenhagen, Universitetsparken 5
Michael G. Palmgren: Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
Poul Nissen: Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark

Nature, 2012, vol. 491, issue 7424, 468-472

Abstract: Detailed characterization of the regulatory domain of a plasma-membrane Ca2+-ATPase — a calcium pump — in complex with calmodulin results in a two-step structural model that explains how calmodulin-mediated regulation of pump activation affords highly responsive control over the intracellular calcium concentration in eukaryotes.

Date: 2012
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DOI: 10.1038/nature11539

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