Endothelial cell expression of haemoglobin α regulates nitric oxide signalling

Adam C. Straub, Alexander W. Lohman, Marie Billaud, Scott R. Johnstone, Scott T. Dwyer, Monica Y. Lee, Pamela Schoppee Bortz, Angela K. Best, Linda Columbus, Benjamin Gaston and Brant E. Isakson ()
Additional contact information
Adam C. Straub: Robert M. Berne Cardiovascular Research Center, University of Virginia
Alexander W. Lohman: Robert M. Berne Cardiovascular Research Center, University of Virginia
Marie Billaud: Robert M. Berne Cardiovascular Research Center, University of Virginia
Scott R. Johnstone: Robert M. Berne Cardiovascular Research Center, University of Virginia
Scott T. Dwyer: University of Virginia
Monica Y. Lee: Robert M. Berne Cardiovascular Research Center, University of Virginia
Pamela Schoppee Bortz: Robert M. Berne Cardiovascular Research Center, University of Virginia
Angela K. Best: Robert M. Berne Cardiovascular Research Center, University of Virginia
Linda Columbus: University of Virginia
Benjamin Gaston: University of Virginia
Brant E. Isakson: Robert M. Berne Cardiovascular Research Center, University of Virginia

Nature, 2012, vol. 491, issue 7424, 473-477

Abstract: This study presents a new model for the regulation of nitric oxide signalling in endothelial cells; the oxidation state of endothelial haemoglobin α, controlled by cytochrome B5 reductase 3, regulates nitric oxide bioactivity and diffusion towards its vascular smooth muscle targets.

Date: 2012
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DOI: 10.1038/nature11626

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