Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts

Dhvanit I. Shah, Naoko Takahashi-Makise, Jeffrey D. Cooney, Liangtao Li, Iman J. Schultz, Eric L. Pierce, Anupama Narla, Alexandra Seguin, Shilpa M. Hattangadi, Amy E. Medlock, Nathaniel B. Langer, Tamara A. Dailey, Slater N. Hurst, Danilo Faccenda, Jessica M. Wiwczar, Spencer K. Heggers, Guillaume Vogin, Wen Chen, Caiyong Chen, Dean R. Campagna, Carlo Brugnara, Yi Zhou, Benjamin L. Ebert, Nika N. Danial, Mark D. Fleming, Diane M. Ward, Michelangelo Campanella, Harry A. Dailey (), Jerry Kaplan () and Barry H. Paw ()
Additional contact information
Dhvanit I. Shah: Brigham and Women’s Hospital, Harvard Medical School
Naoko Takahashi-Makise: University of Utah School of Medicine, Salt Lake City, Utah 84312, USA
Jeffrey D. Cooney: Brigham and Women’s Hospital, Harvard Medical School
Liangtao Li: University of Utah School of Medicine, Salt Lake City, Utah 84312, USA
Iman J. Schultz: Brigham and Women’s Hospital, Harvard Medical School
Eric L. Pierce: Brigham and Women’s Hospital, Harvard Medical School
Anupama Narla: Brigham and Women’s Hospital, Harvard Medical School
Alexandra Seguin: University of Utah School of Medicine, Salt Lake City, Utah 84312, USA
Shilpa M. Hattangadi: Boston Children’s Hospital, Harvard Medical School
Amy E. Medlock: Biomedical and Health Sciences Institute, Biochemistry & Molecular Biology, University of Georgia
Nathaniel B. Langer: Brigham and Women’s Hospital, Harvard Medical School
Tamara A. Dailey: Biomedical and Health Sciences Institute, Biochemistry & Molecular Biology, University of Georgia
Slater N. Hurst: Brigham and Women’s Hospital, Harvard Medical School
Danilo Faccenda: Royal Veterinary College, University of London and University College London Consortium for Mitochondrial Research, London NW1 0TU, UK
Jessica M. Wiwczar: Dana-Farber Cancer Institute, Harvard Medical School
Spencer K. Heggers: Brigham and Women’s Hospital, Harvard Medical School
Guillaume Vogin: Brigham and Women’s Hospital, Harvard Medical School
Wen Chen: Brigham and Women’s Hospital, Harvard Medical School
Caiyong Chen: Brigham and Women’s Hospital, Harvard Medical School
Dean R. Campagna: Boston Children’s Hospital, Harvard Medical School
Carlo Brugnara: Boston Children’s Hospital, Harvard Medical School
Yi Zhou: Boston Children’s Hospital, Harvard Medical School
Benjamin L. Ebert: Brigham and Women’s Hospital, Harvard Medical School
Nika N. Danial: Dana-Farber Cancer Institute, Harvard Medical School
Mark D. Fleming: Boston Children’s Hospital, Harvard Medical School
Diane M. Ward: University of Utah School of Medicine, Salt Lake City, Utah 84312, USA
Michelangelo Campanella: Royal Veterinary College, University of London and University College London Consortium for Mitochondrial Research, London NW1 0TU, UK
Harry A. Dailey: Biomedical and Health Sciences Institute, Biochemistry & Molecular Biology, University of Georgia
Jerry Kaplan: University of Utah School of Medicine, Salt Lake City, Utah 84312, USA
Barry H. Paw: Brigham and Women’s Hospital, Harvard Medical School

Nature, 2012, vol. 491, issue 7425, 608-612

Abstract: Atpif1, a mitochondrial ATPase inhibitor, was identified as a zebrafish anemic mutant, pinotage, providing an important link in our understanding of the relationship between mitochondrial homeostasis and haem synthesis and identifying a gene that may have a role in human iron, haem and mitochondrial diseases.

Date: 2012
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DOI: 10.1038/nature11536

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