Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor

Beomkyu Kim, Alexander Eggel, Svetlana S. Tarchevskaya, Monique Vogel, Heino Prinz and Theodore S. Jardetzky ()
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Beomkyu Kim: Stanford University School of Medicine
Alexander Eggel: Institute of Immunology, University of Bern, CH-3010 Bern, Switzerland
Svetlana S. Tarchevskaya: Stanford University School of Medicine
Monique Vogel: Institute of Immunology, University of Bern, CH-3010 Bern, Switzerland
Heino Prinz: Max-Planck-Institut fur Molekulare Physiologie, Otto-Hahn-Str. 11, 44227 Dortmund, Germany
Theodore S. Jardetzky: Stanford University School of Medicine

Nature, 2012, vol. 491, issue 7425, 613-617

Abstract: The interaction between IgE and its receptor FcεRI underlies many allergic responses; here the structure and mechanism of a newly engineered DARPin inhibitor is presented, revealing that it not only blocks the receptor–ligand interaction but also dissociates already-formed complexes.

Date: 2012
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DOI: 10.1038/nature11546

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