BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs

Rebecca Mathew, Michael P. Seiler, Seth T. Scanlon, Ai-ping Mao, Michael G. Constantinides, Clara Bertozzi-Villa, Jeffrey D. Singer and Albert Bendelac ()
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Rebecca Mathew: Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago
Michael P. Seiler: Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago
Seth T. Scanlon: Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago
Ai-ping Mao: Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago
Michael G. Constantinides: Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago
Clara Bertozzi-Villa: Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago
Jeffrey D. Singer: Portland State University
Albert Bendelac: Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago

Nature, 2012, vol. 491, issue 7425, 618-621

Abstract: The E3 ubiquitin ligase cullin 3 is shown to bind BTB-zinc finger transcription factors to direct the ubiquitination of nuclear chromatin-associated factors to control transcription and cell-fate decisions in B- and T-cell populations.

Date: 2012
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DOI: 10.1038/nature11548

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