Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

Guang-Hui Liu (), Jing Qu, Keiichiro Suzuki, Emmanuel Nivet, Mo Li, Nuria Montserrat, Fei Yi, Xiuling Xu, Sergio Ruiz, Weiqi Zhang, Ulrich Wagner, Audrey Kim, Bing Ren, Ying Li, April Goebl, Jessica Kim, Rupa Devi Soligalla, Ilir Dubova, James Thompson, John Yates, Concepcion Rodriguez Esteban, Ignacio Sancho-Martinez and Juan Carlos Izpisua Belmonte ()
Additional contact information
Guang-Hui Liu: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jing Qu: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Keiichiro Suzuki: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Emmanuel Nivet: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Mo Li: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nuria Montserrat: Center for Regenerative Medicine in Barcelona, Doctor Aiguader 88, 08003 Barcelona, Spain
Fei Yi: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Xiuling Xu: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Sergio Ruiz: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Weiqi Zhang: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Ulrich Wagner: Ludwig Institute for Cancer Research, University of California, San Diego School of Medicine
Audrey Kim: Ludwig Institute for Cancer Research, University of California, San Diego School of Medicine
Bing Ren: Ludwig Institute for Cancer Research, University of California, San Diego School of Medicine
Ying Li: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
April Goebl: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Jessica Kim: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Rupa Devi Soligalla: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Ilir Dubova: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
James Thompson: Scripps Research Institute
John Yates: Scripps Research Institute
Concepcion Rodriguez Esteban: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Ignacio Sancho-Martinez: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Juan Carlos Izpisua Belmonte: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA

Nature, 2012, vol. 491, issue 7425, 603-607

Abstract: Investigation of neural cells from post-mortem human brains and differentiated from patient-derived induced pluripotent stem cells shows that the LRRK2 mutation (G2019S) associated with familial and sporadic Parkinson's disease correlates with abnormalities at the nuclear envelope.

Date: 2012
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DOI: 10.1038/nature11557

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