Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme

Julie B. Sneddon, Malgorzata Borowiak and Douglas A. Melton ()
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Julie B. Sneddon: Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138 USA
Malgorzata Borowiak: Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138 USA
Douglas A. Melton: Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138 USA

Nature, 2012, vol. 491, issue 7426, 765-768

Abstract: The pancreatic lineage is used as a model for embryonic-stem-cell differentiation, and shows that co-culture with organ-matched mesenchyme permits proliferation and self-renewal of progenitors, enabling an expansion of more than a million-fold for human endodermal cells with full retention of developmental potential.

Date: 2012
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DOI: 10.1038/nature11463

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