Resurrection of endogenous retroviruses in antibody-deficient mice

George R. Young, Urszula Eksmond, Rosalba Salcedo, Lena Alexopoulou, Jonathan P. Stoye and George Kassiotis ()
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George R. Young: MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
Urszula Eksmond: MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
Rosalba Salcedo: Basic Science Program, SAIC-Frederick, Inc. and Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute
Lena Alexopoulou: Centre d’Immunologie de Marseille-Luminy (CIML), Aix-Marseille University-UM2, INSERM-U1104, CNRS-UMR7280, Marseille, France
Jonathan P. Stoye: MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
George Kassiotis: MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK

Nature, 2012, vol. 491, issue 7426, 774-778

Abstract: Novel pathogenic infectious retroviruses, generated by recombination between replication-defective endogenous retroviruses in the absence of a functional antibody response, are identified; these recombinant retroviruses establish infection of mouse colonies and ultimately cause cancer.

Date: 2012
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DOI: 10.1038/nature11599

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