The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Geun-Shik Lee, Naeha Subramanian, Andrew I. Kim, Ivona Aksentijevich, Raphaela Goldbach-Mansky, David B. Sacks, Ronald N. Germain, Daniel L. Kastner () and Jae Jin Chae ()
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Geun-Shik Lee: Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health
Naeha Subramanian: Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Andrew I. Kim: Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health
Ivona Aksentijevich: Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health
Raphaela Goldbach-Mansky: Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
David B. Sacks: Clinical Center, National Institutes of Health
Ronald N. Germain: Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Daniel L. Kastner: Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health
Jae Jin Chae: Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health

Nature, 2012, vol. 492, issue 7427, 123-127

Abstract: Evidence is presented that activation of the NLRP3 inflammasome is regulated by the calcium-sensing receptor (CASR).

Date: 2012
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DOI: 10.1038/nature11588

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