HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

Florian Klein, Ariel Halper-Stromberg, Joshua A. Horwitz, Henning Gruell, Johannes F. Scheid, Stylianos Bournazos, Hugo Mouquet, Linda A. Spatz, Ron Diskin, Alexander Abadir, Trinity Zang, Marcus Dorner, Eva Billerbeck, Rachael N. Labitt, Christian Gaebler, Paola M. Marcovecchio, Reha-Baris Incesu, Thomas R. Eisenreich, Paul D. Bieniasz, Michael S. Seaman, Pamela J. Bjorkman, Jeffrey V. Ravetch, Alexander Ploss and Michel C. Nussenzweig ()
Additional contact information
Florian Klein: Laboratory of Molecular Immunology, The Rockefeller University
Ariel Halper-Stromberg: Laboratory of Molecular Immunology, The Rockefeller University
Joshua A. Horwitz: Laboratory of Molecular Immunology, The Rockefeller University
Henning Gruell: Laboratory of Molecular Immunology, The Rockefeller University
Johannes F. Scheid: Laboratory of Molecular Immunology, The Rockefeller University
Stylianos Bournazos: Laboratory of Molecular Genetics and Immunology, The Rockefeller University
Hugo Mouquet: Laboratory of Molecular Immunology, The Rockefeller University
Linda A. Spatz: Laboratory of Molecular Immunology, The Rockefeller University
Ron Diskin: California Institute of Technology
Alexander Abadir: Laboratory of Molecular Immunology, The Rockefeller University
Trinity Zang: Aaron Diamond AIDS Research Center, Laboratory of Retrovirology, The Rockefeller University
Marcus Dorner: Laboratory of Virology and Infectious Diseases, The Rockefeller University
Eva Billerbeck: Laboratory of Virology and Infectious Diseases, The Rockefeller University
Rachael N. Labitt: Laboratory of Virology and Infectious Diseases, The Rockefeller University
Christian Gaebler: Laboratory of Molecular Immunology, The Rockefeller University
Paola M. Marcovecchio: California Institute of Technology
Reha-Baris Incesu: Laboratory of Molecular Immunology, The Rockefeller University
Thomas R. Eisenreich: Laboratory of Molecular Immunology, The Rockefeller University
Paul D. Bieniasz: Aaron Diamond AIDS Research Center, Laboratory of Retrovirology, The Rockefeller University
Michael S. Seaman: Beth Israel Deaconess Medical Center
Pamela J. Bjorkman: California Institute of Technology
Jeffrey V. Ravetch: Laboratory of Molecular Genetics and Immunology, The Rockefeller University
Alexander Ploss: Laboratory of Virology and Infectious Diseases, The Rockefeller University
Michel C. Nussenzweig: Laboratory of Molecular Immunology, The Rockefeller University

Nature, 2012, vol. 492, issue 7427, 118-122

Abstract: Passive immunotherapy with a combination of neutralizing monoclonal antibodies is shown to be effective in suppressing HIV replication in a humanized mouse model.

Date: 2012
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DOI: 10.1038/nature11604

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