B12 cofactors directly stabilize an mRNA regulatory switch

James E. Johnson, Francis E. Reyes (), Jacob T. Polaski and Robert T. Batey ()
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James E. Johnson: University of Colorado at Boulder, UCB 596, Boulder, Colorado 80309-0596, USA
Francis E. Reyes: University of Colorado at Boulder, UCB 596, Boulder, Colorado 80309-0596, USA
Jacob T. Polaski: University of Colorado at Boulder, UCB 596, Boulder, Colorado 80309-0596, USA
Robert T. Batey: University of Colorado at Boulder, UCB 596, Boulder, Colorado 80309-0596, USA

Nature, 2012, vol. 492, issue 7427, 133-137

Abstract: The crystal structures of two different cobalamin (vitamin B12)-binding riboswitches are determined; the structures reveal how cobalamin facilitates interdomain interactions to regulate gene expression.

Date: 2012
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DOI: 10.1038/nature11607

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