Practical and innate carbon–hydrogen functionalization of heterocycles

Yuta Fujiwara, Janice A. Dixon, Fionn O’Hara, Erik Daa Funder, Darryl D. Dixon, Rodrigo A. Rodriguez, Ryan D. Baxter, Bart Herlé, Neal Sach, Michael R. Collins, Yoshihiro Ishihara and Phil S. Baran ()
Additional contact information
Yuta Fujiwara: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Janice A. Dixon: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Fionn O’Hara: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Erik Daa Funder: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Darryl D. Dixon: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Rodrigo A. Rodriguez: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Ryan D. Baxter: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Bart Herlé: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Neal Sach: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Michael R. Collins: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Yoshihiro Ishihara: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Phil S. Baran: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA

Nature, 2012, vol. 492, issue 7427, 95-99

Abstract: It is shown that zinc sulphinate salts can be used to transfer alkyl radicals to heterocycles, allowing for the mild, direct and operationally simple formation of medicinally relevant carbon–carbon bonds while reacting in a complementary fashion to other innate carbon–hydrogen functionalization methods.

Date: 2012
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DOI: 10.1038/nature11680

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