An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

Fernando Geu-Flores, Nathaniel H. Sherden, Vincent Courdavault, Vincent Burlat, Weslee S. Glenn, Cen Wu, Ezekiel Nims, Yuehua Cui and Sarah E. O’Connor
Additional contact information
Fernando Geu-Flores: John Innes Centre, Norwich NR4 7UH, UK
Nathaniel H. Sherden: John Innes Centre, Norwich NR4 7UH, UK
Vincent Courdavault: Université François-Rabelais de Tours, EA2106, Biomolécules et Biotechnologies Végétales, 37200 Tours, France
Vincent Burlat: Université de Toulouse, UPS, UMR 5546, Laboratoire de Recherche en Sciences Végétales, BP 42617 Auzeville, F-31326 Castanet-Tolosan, France
Weslee S. Glenn: John Innes Centre, Norwich NR4 7UH, UK
Cen Wu: Michigan State University, East Lansing, Michigan 48824, USA
Ezekiel Nims: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Yuehua Cui: Michigan State University, East Lansing, Michigan 48824, USA
Sarah E. O’Connor: John Innes Centre, Norwich NR4 7UH, UK

Nature, 2012, vol. 492, issue 7427, 138-142

Abstract: Iridoids are a large family of bicyclic natural products that possess anticancer, anti-inflammatory, antifungal and antibacterial activities; here the essential cyclization step in their biosynthesis is identified, opening up the possibility of production of naturally occurring and synthetic variants of iridoids for use in pharmacy or agriculture.

Date: 2012
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DOI: 10.1038/nature11692

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