Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability

Weiquan Zhu, Nyall R. London, Christopher C. Gibson, Chadwick T. Davis, Zongzhong Tong, Lise K. Sorensen, Dallas S. Shi, Jinping Guo, Matthew C. P. Smith, Allie H. Grossmann, Kirk R. Thomas and Dean Y. Li ()
Additional contact information
Weiquan Zhu: University of Utah
Nyall R. London: University of Utah
Christopher C. Gibson: Program in Molecular Medicine, University of Utah
Chadwick T. Davis: Program in Molecular Medicine, University of Utah
Zongzhong Tong: Navigen Inc
Lise K. Sorensen: Program in Molecular Medicine, University of Utah
Dallas S. Shi: Program in Molecular Medicine, University of Utah
Jinping Guo: University of Utah
Matthew C. P. Smith: University of Utah
Allie H. Grossmann: Program in Molecular Medicine, University of Utah
Kirk R. Thomas: University of Utah
Dean Y. Li: University of Utah

Nature, 2012, vol. 492, issue 7428, 252-255

Abstract: Interleukin-1β-induced disruption to endothelial stability and vascular permeability in a human in vitro model is shown to be independent of downstream nuclear factor-κB activation, relying instead on a MYD88–ARNO–ARF6 signalling cascade; inhibiting proteins involved in this pathway is shown to improve outcomes in animal models of inflammatory disease.

Date: 2012
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DOI: 10.1038/nature11603

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