The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

Jayakrishnan Nandakumar, Caitlin F. Bell, Ina Weidenfeld, Arthur J. Zaug, Leslie A. Leinwand and Thomas R. Cech ()
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Jayakrishnan Nandakumar: University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
Caitlin F. Bell: University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
Ina Weidenfeld: University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
Arthur J. Zaug: University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
Leslie A. Leinwand: University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
Thomas R. Cech: University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA

Nature, 2012, vol. 492, issue 7428, 285-289

Abstract: Using separation-of-function mutations of TPP1 that inhibit telomerase binding while maintaining telomere capping, a region on the surface of TPP1, the TEL patch, is identified and found to be required for both binding telomerase and enhancing its processivity.

Date: 2012
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DOI: 10.1038/nature11648

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