An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

Adam L. Hughes and Daniel E. Gottschling ()
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Adam L. Hughes: Fred Hutchinson Cancer Research Center
Daniel E. Gottschling: Fred Hutchinson Cancer Research Center

Nature, 2012, vol. 492, issue 7428, 261-265

Abstract: Vacuolar acidity in yeast is shown to decline with age, and preventing this decrease suppresses mitochondrial dysfunction and extends the lifespan of yeast.

Date: 2012
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DOI: 10.1038/nature11654

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