Ubiquitin chain conformation regulates recognition and activity of interacting proteins

Yu Ye, Georg Blaser, Mathew H. Horrocks, Maria J. Ruedas-Rama, Shehu Ibrahim, Alexander A. Zhukov, Angel Orte, David Klenerman (), Sophie E. Jackson () and David Komander ()
Additional contact information
Yu Ye: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
Georg Blaser: University of Cambridge, Cambridge CB2 1EW, UK
Mathew H. Horrocks: University of Cambridge, Cambridge CB2 1EW, UK
Maria J. Ruedas-Rama: Faculty of Pharmacy, University of Granada, Campus Cartuja, 18071 Granada, Spain
Shehu Ibrahim: University of Cambridge, Cambridge CB2 1EW, UK
Alexander A. Zhukov: University of Cambridge, Cambridge CB2 1EW, UK
Angel Orte: Faculty of Pharmacy, University of Granada, Campus Cartuja, 18071 Granada, Spain
David Klenerman: University of Cambridge, Cambridge CB2 1EW, UK
Sophie E. Jackson: University of Cambridge, Cambridge CB2 1EW, UK
David Komander: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK

Nature, 2012, vol. 492, issue 7428, 266-270

Abstract: Single-molecule FRET assays used to probe the conformational dynamics of ubiquitin chains reveal that conformational selection is an important mechanism of ubiquitin chain recognition.

Date: 2012
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DOI: 10.1038/nature11722

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