Activated GTPase movement on an RNA scaffold drives co-translational protein targeting

Kuang Shen, Sinan Arslan, David Akopian, Taekjip Ha and Shu-ou Shan ()
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Kuang Shen: California Institute of Technology
Sinan Arslan: Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign
David Akopian: California Institute of Technology
Taekjip Ha: Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign
Shu-ou Shan: California Institute of Technology

Nature, 2012, vol. 492, issue 7428, 271-275

Abstract: Single-molecule fluorescence microscopy techniques are used to elucidate features of the highly conserved protein-targeting machinery known as the signal recognition particle (SRP); the long SRP RNA is shown to be crucial for correct timing and precision of cargo handover to the protein-translocation machinery, a finding that could help to explain how other ribonucleosome complexes function during complex cellular processes.

Date: 2012
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DOI: 10.1038/nature11726

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