Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis

Sergey Lekomtsev, Kuan-Chung Su, Valerie E. Pye, Ken Blight, Sriramkumar Sundaramoorthy, Tohru Takaki, Lucy M. Collinson, Peter Cherepanov, Nullin Divecha and Mark Petronczki ()
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Sergey Lekomtsev: Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK
Kuan-Chung Su: Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK
Valerie E. Pye: Chromatin Structure and Mobile DNA Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK
Ken Blight: Electron Microscopy Unit, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
Sriramkumar Sundaramoorthy: Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK
Tohru Takaki: Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK
Lucy M. Collinson: Electron Microscopy Unit, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
Peter Cherepanov: Chromatin Structure and Mobile DNA Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK
Nullin Divecha: Inositide Laboratory, Paterson Institute for Cancer Research, The University of Manchester, Wilmslow Road, Withington, Manchester M20 4BX, UK
Mark Petronczki: Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK

Nature, 2012, vol. 492, issue 7428, 276-279

Abstract: Structural and functional analysis of the centralspindlin complex shows that it connects the mitotic spindle to the plasma membrane during cytokinesis through interactions of the C1 domain of centralspindlin’s MgcRacGAP subunit with phosphoinositide lipids.

Date: 2012
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DOI: 10.1038/nature11773

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