A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

Melissa R. Warden (), Aslihan Selimbeyoglu, Julie J. Mirzabekov, Maisie Lo, Kimberly R. Thompson, Sung-Yon Kim, Avishek Adhikari, Kay M. Tye, Loren M. Frank and Karl Deisseroth ()
Additional contact information
Melissa R. Warden: Stanford University
Aslihan Selimbeyoglu: Stanford University
Julie J. Mirzabekov: Stanford University
Maisie Lo: Bio-X Program, Stanford University
Kimberly R. Thompson: Stanford University
Sung-Yon Kim: Stanford University
Avishek Adhikari: Stanford University
Kay M. Tye: Stanford University
Loren M. Frank: University of California San Francisco
Karl Deisseroth: Stanford University

Nature, 2012, vol. 492, issue 7429, 428-432

Abstract: High-speed tracking of effortful responses and neuronal activity in rats during a forced swim test identifies medial prefrontal cortex (mPFC) neurons that respond during escape-related swimming but not normal locomotion, and optogenetics shows that mPFC neurons projecting to the brainstem dorsal raphe nucleus, which is implicated in depression, modulate this behavioural response to challenge

Date: 2012
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DOI: 10.1038/nature11617

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