Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells

Alexej Abyzov, Jessica Mariani, Dean Palejev, Ying Zhang, Michael Seamus Haney, Livia Tomasini, Anthony F. Ferrandino, Lior A. Rosenberg Belmaker, Anna Szekely, Michael Wilson, Arif Kocabas, Nathaniel E. Calixto, Elena L. Grigorenko, Anita Huttner, Katarzyna Chawarska, Sherman Weissman, Alexander Eckehart Urban (), Mark Gerstein () and Flora M. Vaccarino ()
Additional contact information
Alexej Abyzov: Program in Neurodevelopment and Regeneration, Yale University
Jessica Mariani: Program in Neurodevelopment and Regeneration, Yale University
Dean Palejev: Program in Neurodevelopment and Regeneration, Yale University
Ying Zhang: Program in Neurodevelopment and Regeneration, Yale University
Michael Seamus Haney: Stanford University
Livia Tomasini: Program in Neurodevelopment and Regeneration, Yale University
Anthony F. Ferrandino: Program in Neurodevelopment and Regeneration, Yale University
Lior A. Rosenberg Belmaker: Program in Neurodevelopment and Regeneration, Yale University
Anna Szekely: Program in Neurodevelopment and Regeneration, Yale University
Michael Wilson: Program in Neurodevelopment and Regeneration, Yale University
Arif Kocabas: Program in Neurodevelopment and Regeneration, Yale University
Nathaniel E. Calixto: Program in Neurodevelopment and Regeneration, Yale University
Elena L. Grigorenko: Program in Neurodevelopment and Regeneration, Yale University
Anita Huttner: Program in Neurodevelopment and Regeneration, Yale University
Katarzyna Chawarska: Program in Neurodevelopment and Regeneration, Yale University
Sherman Weissman: Program in Neurodevelopment and Regeneration, Yale University
Alexander Eckehart Urban: Program in Neurodevelopment and Regeneration, Yale University
Mark Gerstein: Program in Neurodevelopment and Regeneration, Yale University
Flora M. Vaccarino: Program in Neurodevelopment and Regeneration, Yale University

Nature, 2012, vol. 492, issue 7429, 438-442

Abstract: A whole-genome and transcriptome analysis of 20 human induced pluripotent stem-cell lines shows that reprogramming does not necessarily add de novo copy number variants to what is already present in the somatic cells from which they originated.

Date: 2012
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DOI: 10.1038/nature11629

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